What is skin-aging?

Both tangible and intangible changes to the skin occur as one gets old

face lifting

"All information depicted and explained in this site are intended for foreign customers."

Anti-aging by mechanotransduction
face lifting

Everyone has a strong desire to be young and sustain his or her youth. As one gets old, fine and thick wrinkles, loss of elasticity, expansion of pores, darkened skin tone, dryness are internally happening within skin and externally skin aging occurs because of thick wrinkles, hyperpigmentation, loss of elasticity, freckles, skin roughness, vasodilation, etc.

As time passes by, physical functions atrophy and the aging is definitely a natural process. We may not be able to stop the human body clock, but we can slow down the aging process if skin treatment is conducted well with regenerative medicine, not with a surgery.

Pathophysiological aging mechanism
Existing causes
  1. excessive oxidative phospholyation with an accumulation of superoxide
  2. active fibroblast reduction collagen & GAG reduction
Recently increased causes
  1. MMPs overproductione connective tissue destruction increase
  2. reduced production of HSPs fibroblast activity & collagen production decrease

Decrease of Collagen

MMP(matrix metaloproteinanase) Activation  Dermal collagen matrix fragmentation  Fibroblast  and collagen connection defect/Fibroblast collapse/Fibroblast function defect/decreased mechanical tension,  decreased procollagen production increased collagenase production

Causes of aging

Skin aging occurs through the following two processes.

  1. 01

    Intrinsic aging

    Intrinsic aging obviously occurs to anyone with the passing of time, not by any particular environmental factors. It occurs as damage in components in our body is accumulated by reactive oxygen free radical produced during the metabolic process. However, skin damage is caused by a series of inflammation when oxygen free radical in body is not well removed with some protective device after oxygen free radical is produced.

  2. 02

    Photoaging

    Photoaging refers to changes on face, neck and hands when exposed to environmental factors like sunlight for a long time. It has become a main cause of most of cosmetic and medical skin problems. Action spectrum which leads to photoaging is under ultraviolet region, and not only ultraviolet B but also ultraviolet A (UVA, 320~400nm) causes skin aging and cancer.

  3. 03

    Other factors

    Other factors like sunlight, ultraviolet, infrared light, smoking, drug-taking, menopause, etc. are related.

The needs for anti-aging

Skin aging includes both tangible and intangible skin changes with advancing years. Skin is a protective coating with several physiological functions, and at the same time, a vital organ for attracting engaging beauty from others. Aging skin is accompanied by some skin functional disorders along with changes on the surface. Besides, the results from severe aging have a great effect on life, so some people eventually suffer from depression. Thus, more active endeavor is expected to prevent and minimize skin-aging.

Mechanotransduction?

‘The conversion of a mechanical stimulus into
chemical activity‘

thread face lift

"All information depicted and explained in this site are intended for foreign customers."

What is Mechanotransduction?

Mechanotransduction is a mechanism which brings about changes within a cell itself by constantly providing mechanical stimulus to the cell. The cell has a mechanism that sustains physiological functions by responding to external and mechanical stimulus. Regulation of plasma cells, protein synthesis, growth of cells, and especially operations that overcome pathological disease are called mechanotransduction. When PDO thread is inserted into skin layers, it operates as mechanical stimulus to the cell and finally collagen is produced within skin. Also, circulation of microvessel and cell metabolism increase and then all these activities such as tissue adhesion, anchoring effect, decrease of cellulite, relaxation of muscles and increase of lipolysis lead to skin regeneration. When inserting PDO into skin tissue, the changes of surrounding tissues like elasticity and lifting are observed and growth factor EGF, FGF, TGF-ß, IGF, VEGF are measured as indicators to check out cell signaling after mechanotransduction which has an impact on regeneration and cell activity of skin and subcutaneous tissue. As a result, more than 300 times for EGF, more than 350 times for FGF, more than 400 times for IGF, more than 150 times for TGF-ß, more than 1000 times for VEGF are increased.

Mechanical stimulus within skin tissue
thread face lift

According to acupuncture study conducted by American neurologist, it is claimed that a chain of response from fibroblast occurred as cell is crushed within extracellular matrix and fibroblast when surrounding tissue is twisted by needle’s turn within loose connective tissue layer and finally needle grasp phenomenon occurs instantly during acupuncture. Besides, degeneration of tissue may occur eventually as protein production and cell division are involved via cell signaling route system connected from cell membrane to nucleus.
Likewise, several biochemical operations are conducted within cells for maintaining cellular homeostasis when the shape of the cell is twisted and, with this result, phenomenon that has an impact on gene-expression, cell division, and tissue proliferation is called mechanotransduction. Not only in loose connective tissue layer, but also in other tissues such as muscle, bone, fat, skin, etc. mechanical stimulus affects cell nucleus via cell membrane and pathway with particular enzymes. And this has recently become one of the hottest items on which many researches are conducted among many different medical fields such as orthopedics, oncology, dermatology, bariatrics, etc.

Resource : 「Regenerative medicine PDO using mechanical stimulus」 Junghyun Yoon, Sangsung Kim, Dae Il Kim, N. Finders Co., Ltd., 2013.

PDO Thread is Mechanotransduction Mechanism
  1. 01

    Neocollagenesis by PDO Foreign material

  2. 02

    Neovascularization : Microcirculation Increase

  3. 03

    Metabolism Increase : Growth Factor Increase

  4. 04

    Tissue adhesion & Anchoring effect around PDO

  5. 05

    Lipolysis Increase & Cellulite Decrease

  6. 06

    Muscle Relaxation

Resource : “Basic Theory of Nonbarbed Absorbable Suture Network
Tightening and Lifting” - By jung hyun yoon

What is PDO?

‘Polydioxanone‘

PDO thread

"All information depicted and explained in this site are intended for foreign customers."

What is PDO?

Abbreviation of polydioxanone
Colorless crystal form, biodegradable synthetic polymer
Monofilament
Degradable by hydrolysis
Mainly excreted by urine
Period of biodegradation: 6-8 months

PDO thread

PDO is an abbreviation of polydioxanone, and is widely used as surgery stitch thread which is also safe to human body. As a colorless biodegradable synthetic polymer, it is a monofilament, so hydrolyzed in body and then naturally excreted by urine within 6 months. Thus, PDO is safe to human body. PDO procedure leads to mechanotransduction within skin by forming vector among fine threads (FT) when FT is inserted in a fixed direction. Inserted PDO operates in the cell as mechanical external stimulus, and brings about the following effects by providing external stimulus within skin.

  1. Production of collagen
  2. Circulation of microvessel
  3. Increase of cell metabolism
  4. Surrounding tissue adhesion
  5. Surrounding tissue anchoring
  6. Decrease of cellulite
  7. Relaxation of muscles
  8. Increase of lipolysis
  9. Inducement of skin regeneration
  10. Regeneration and cellular activities of skin and subcutaneous tissue
  11. More than 300 times increase of EGF
  12. More than 350 times increase of FGF
  13. More than 400 times increase of IGF
  14. More than 150 times increase of TGF-ß
  15. More than 1000 times increase of VEGF

RE:THREAD MONO

Regenerative PDO Thread RE:

thread lifting

"All information depicted and explained in this site are intended for foreign customers."

What is Regenerative PDO Thread RE: ?
thread lifting

RE: Thread is a product made with surgical sutures and medical needles, and is highly effective in regenerating skin tissue and pain treatment merely via medical procedure, not with a surgical way, so it is acknowledged to be a safe product rated KFDA fourth grade.

It is an innovative non-surgical treatment that creates tightening & lifting effects by establishing fibrous bridging network at which collagen fiber is newly made around PDO through Thread & Tissue reaction.

RE: Thread has not only been proved effective by a clinical trial on mini pig, but also expanded its scope of procedure to treatment on pain and obesity.

  • Thread insertion site;
    Cross section (X200)

  • Collagen;
    Masson Trichrome (X200)

  • Merging Effect
     

  • Fibrous bridging among thread fibrosis, perimysium, dermis

  • reference: animal experiment data by Mini-Pig
    (Reserch by Jung-Hyun Yoon, Sang-Sup Kim, Dae-Il Kim and N-finders.co.Ltd, 2012.)

Changes made while PDO is biodegraded within cell tissue have been directly observed through long-term observation for a year using Yucatan pig which is most closely similar to human anatomy and all this was attempted for the first in the world. As a result, the causes of wrinkle improvement, skin-lightening effect and skin elasticity have been scientifically proved, and directions of vector for wrinkle improvement and collagen formation process and its shape around PDO that is inserted within tissue can be defined.

Effects of RE: THREAD
  1. 01

    Very natural with no scars left after medical procedure

  2. 02

    Experience completely dramatic changes in a very short time for about 10 minutes with minimal invasive procedure method

  3. 03

    No scar left on face with not even 1mm incision made and no negative effect to daily life as no other recovery needed

  4. 04

    Unlike other lifting procedures, immediate effects can be experienced. And synergy effect is maximized if RE: Thread is used with other procedures jointly.

N-COG

‘Newton Cog’
Isac Newton, who suggested the law of gravity, did not even know.

cog thread

"All information depicted and explained in this site are intended for foreign customers."

cog thread

N-COG is an acronym of Newton Cog which prevents wrinkled skin with the equal pull caused by stress dispersion during a procedure. It also cuts down side effects of breaking through skin caused by a mass of short cog, and minimizes inflammatory response by inserting thin cog thread. As a new type of thread with processus produced by inserting short two-way processus into PDO thread, pressure that the tissue delivers to thread is effectively dispersed because of holding effect of short processus, and finally adequate tissue contouring is also possible.

Benefits of N-COG

N-COG is the COG Thread of new technology which makes up for the weakness such as breaking through of skin unfixed and moving around or a break when the existing thread with processus, either one-way or two-way, is inserted in skin. It also has a strong benefit of evenly pulling overall part where procedure has been conducted, not a partial pull, by efficiently designing for skin pull considering directions and angle of COG.

  1. 01

    To prevent a phenomenon of wrinkled skin by dispersing gravity force of the tissue which is caught in processus

  2. 02

    Equal pull by dispersing stress

  3. 03

    To maximize bond between thread and tissue by dispersing both force and stress

  4. 04

    To form effective force merely with thin thread

  5. 05

    Applicable to various parts: skin around eyes, wrinkles formed around mouth, marionette lines, etc.

  6. 06

    No protruding thread through skin as less motion in skin is detected and it is well fixed in the tissue because of a mass of short processus

  7. 07

    To minimize pain and less irritating feeling after procedure compared to other threads with processus

  8. 08

    Simple procedure is available using less number of threads

  9. 09

    Contouring effect is seen through simple procedure

Comparison of existing COG thread and N-COG

N-COG (Newton cog) was designed based on discovery of the law of gravity, and is a product which prevents flabby skin mainly caused by gravity. It has also been produced considering physical force created between cog and tissue through scientific research and its effectiveness has been proved through previous clinical trials on rats and pigs.

N-COG in Mice Test
  • Bidirectional COG :
    In a region where the thread was inserted, severe contouring occurred, which led to asymmetric and irregular folding of skins.


  • Multidirectional N-COG :
    From a region where the thread was inserted to a region where the end of thread was located, no contouring occurred whereas the shape of flat plate was formed inside the skin tissue through the distribution of appropriate force.

N-COG reduces a phenomenon of thread’s breaks by force is leaning to one side due to the nature of design of COG thread. Thus, it lessens thread’s breaks and precisely contours by dispersing force evenly and widely to whole parts of thread.

DERMA SPRING

‘The spring on my face’ PDO spring in skin? Amazingly elastic!

spring thread

"All information depicted and explained in this site are intended for foreign customers."

spring thread
What is Derma spring?

Spring-shaped PDO of high elasticity by special methods.
Derma spring is made to keep its own ability of restoration with the spring-like thread by hardening it after making turns to one direction and compresses better with physical stimulus upon tissue than normal plane PDO. The spring-shaped PDO, Derma-spring maintains original elasticity even when pulled up and down by force. That is, Derma spring plays a great role of maximizing the effects with high elasticity in our skin just as a bouncy spring with its elasticity.

Benefits of Derma-Spring
  1. 01

    Spring-shaped PDO with high elasticity by special methods

  2. 02

    Response made between constant physical stimulus and tissue through elasticity

  3. 03

    Increase of collagen synthesis, Increase of secretion of growth factors & cytokines (high concentration effects) 6-0 PDO

  4. 04

    Maximize fibrous bridging effect created between threads by winding up threads around a needle very densely with cylindrical pore

  5. 05

    Argumentation effect by inserting densely wound threads (rolled length 2.0cm, unrolled length 10cm)

  6. 06

    Lifting effect using directions of elasticity

  7. 07

    Constant mechanotransduction effect through elasticity

  8. 08

    Increase of secretion of cytokines

  9. 09

    Lifting effect through collage generated along the line

  10. 10

    Cell cultivation effect using wide contact surface and pore

  11. 11

    Sterilized production for elasticity

  12. 12

    Patented technology maintaining elasticity for 2 years at the longest

Y-KO

MULTI-DIRECTIONAL COGGED THREAD

"All information depicted and explained in this site are intended for foreign customers."

What is Y-KO ?

Y-KO stimulates patient's intrinsic healing process in order to re-shape nose. Expected results are lift of nasal ridge, and shrinkage of nasal base with minimized use of filler and other implant object. It is simpler and safer treatment for nose compare to open Rhinoplasty.
Furthermore PDO plate is used as guide of cartilage regrowth preventing 2nd deviation. Studies showed it's a safe, and stable material to implant it to nose.
Inserted thread works as structural fixture which results in different shape compare to filler, and other injectables. Unlike filler, thread does not influence to shape of nose due to disperse, inflammation, immune response and etc.

Y-KO is unique in term of the way it is barbed. To enhance tissue holding strength, two types of pattern are barbed. One is multi directional cogs and the other is uni-directional cogs. Unlike other thread with bi-directional cogs, it does not cause migration of thread which the main reason of complication or side effect. PDO is proven to be safe for use on nose by utilizing plate form.

Clinical Results

Regenerative PDO Thread RE:

"All information depicted and explained in this site are intended for foreign customers."

Vascularization ? Capillary(left, control)

Vascularization

Large capillary plexus is observed near PDO thread inserted site. Compare to control site, capillary plexus is bigger.

Collagen Synthesis ? Early Stage, 3 Months later

Collagen

After a month of insertion, inflammatory cells near inserted site are observed. After 3 months, dense collagenous fibrosis is formed.

Collagen Bridge formation ? Junction of pre-existing and newly formed collagen

Collagen Bridge formation

Collagen bridge is formed by connecting pre-existing fibrous tissue to newly formed collagen.

Bulge formation after inserting spring typed PDO thread

Bulge formation after inserting spring typed PDO thread

Insertion of 3~5 spring typed PDO thread shows augmentation effect. (R) Inside the tissue, spring shape remains almost same as it was before.

Bi-Directional PDO thread insertion

Bi-Directional PDO thread insertion

Skin is folding in accordance with inserted threads.

Multi-directional PDO thread insertion

Multi-directional PDO thread insertion

Folding is not observed.

DERMA SPRING EYE

MICRO-CANNULA EYE ZONE THREAD

"All information depicted and explained in this site are intended for foreign customers."

What is DERMA SPRING EYE ?

DERMA-SPRING EYE is specially designed for eye area. The special blunt needle allows optimal treatment without side effects. Patient comfort is assured -There is minimized risk of bruise, and edema. PLUS the PDO Thread effects of contouring, neocollagenesis, neovascularization, lipolysis ensure optimal results and patient satisfaction!

MAJOR FEATURES OF DERMA-SPRING EYE
  1. 01

    Less bleeding, swelling and bruising

  2. 02

    Removing dark circle, wrinkles and
    bags under eyes according to the inserting layers

  3. 03

    Efficiently reduces the sagging around eyes

  4. 04

    Continuous skin stimulation from PDO thread

  5. 05

    Increased production of collagen

  6. 06

    Increased secretion of growth factor and cytokines

  7. 07

    Continuous mechanotransduction effect

  8. 08

    100% PDO, a clinically proven bio-compatible material

N-COG SPIRAL

SPIRAL PDO THREAD

"All information depicted and explained in this site are intended for foreign customers."

What is N-COG SPIRAL ?

N-COG Spiral is barbed spirally and multi-directionally. In other word, multi-directional cogs are barbed spirally. This unique feature enhances tissue holding force and makes it very distinctive from other 3D bi-diretional barbed thread. The middle of traditional bi-directionally barbed thread gets the most stress and stress gradually decreases according to the distance from the center. N-COG Spiral PDO thread is designed to achieve that every cogs are stressed almost same as cogs located in the middle of bi-directional thread.

N-COG Spiral PDO Thread has new type of cogs which can distribute stress and hold tissue stronger base on multi-directional cogs. after insertion. If target site is expected to move a lot or anchoring site is weak, N-COG Spiral PDO would be the best option.

  1. 01

    Extra ordinary lifting strength : More anchoring in 360°

  2. 02

    Even distribution of strength : Multi-directional cogs hold tissue more evenly.

  3. 03

    No unexpected results : No dimple, inflammation, and protrusion

  4. 04

    Thin area to thick area : Better performance to all applicable site